Search results for "Monocyte distribution width"

showing 5 items of 5 documents

Pooled analysis of monocyte distribution width in subjects with SARS‐CoV‐2 infection

2021

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Clinical BiochemistryLetter to the EditorsMonocytesLeukocyte CountMDWmedicineDistribution (pharmacology)Humansmonocyte distribution widthLetter to the EditorCell SizeBiochemistry medicalbusiness.industrySARS-CoV-2MonocyteBiochemistry (medical)COVID-19Meta-analysis monocyte distribution width MDW SARS-CoV-2HematologyGeneral MedicinePrognosisVirologyMeta-analysisPooled analysismedicine.anatomical_structurebusinessInternational Journal of Laboratory Hematology
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Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department

2020

Abstract Objectives The diagnosis of sepsis in the Emergency Department (ED) is challenging and a reliable biomarker is needed. The current study aimed to evaluate the diagnostic accuracy of monocyte distribution width (MDW) for the early identification of sepsis in the ED. Methods We performed a large observational study including consecutive adult patients (≥18 years of age) presenting to the ED between September and November 2019, with an order for complete blood count (CBC) evaluation. A total of 2,215 patients were enrolled and classified based on Sepsis-2 criteria as the control group (1,855), infection group (172), Systemic Inflammatory Response Syndrome (SIRS) group (100), and sepsi…

AdultMalemedicine.medical_specialtyClinical BiochemistryEmergency Department (ED)030204 cardiovascular system & hematologyMonocytesCohort StudiesSepsis03 medical and health sciences0302 clinical medicineSepsisInternal medicinemedicineHumansDistribution (pharmacology)sepsis.Agedmedicine.diagnostic_testbusiness.industryscreeningMonocyteBiochemistry (medical)monocyte distribution width (MDW)Complete blood countGeneral MedicineEmergency departmentMiddle Agedmedicine.diseaseinfectionSystemic inflammatory response syndromemedicine.anatomical_structureROC CurveArea Under Curve030220 oncology & carcinogenesismonocyteBiomarker (medicine)FemaleObservational studyEmergency Service HospitalbusinessBiomarkersClinical Chemistry and Laboratory Medicine (CCLM)
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Circulating histones contribute to monocyte and MDW alterations as common mediators in classical and COVID-19 sepsis

2022

Abstract Objective Histone proteins are physiologically involved in DNA packaging and gene regulation but are extracellularly released by neutrophil/monocyte extracellular traps and mediate thrombo-inflammatory pathways, associated to the severity of many human pathologies, including bacterial/fungal sepsis and COVID-19. Prominent and promising laboratory features in classic and viral sepsis emphasize monocyte distribution width (MDW), due to its ability to distinguish and stratify patients at higher risk of critical conditions or death. No data are available on the roles of histones as MDW modifiers. Design Comparison of MDW index was undertaken by routine hematology analyzer on whole bloo…

HistonesCritical careSettore BIO/12 - Biochimica Clinica E Biologia Molecolare ClinicaSepsisHumansCOVID-19Biomarkers; COVID-19; Critical care; Histones; Monocyte; Monocyte distribution width; SepsisCritical Care and Intensive Care MedicineMonocyteMonocytesBiomarkersMonocyte distribution width
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Time-dependent stability of monocyte distribution width (MDW)

2022

Leukocyte CountSettore BIO/12 - Biochimica Clinica E Biologia Molecolare ClinicaMDWSepsisBiochemistry (medical)Clinical BiochemistryHumansGeneral MedicineAnalyticalBiochemistryMonocytesMonocyte distribution widthClinica Chimica Acta
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A new tool for sepsis screening in the Emergency Department

2021

Abstract Objectives In this study, we developed and evaluated the diagnostic accuracy of the Sepsis Index for early sepsis screening in the Emergency Department (ED). Methods Sepsis Index is based on the combination of monocyte distribution width (MDW) and mean monocyte volume (MMV). Sepsis Index≥1 was selected to define sepsis. We tested its diagnostic accuracy in an ED population stratified in four groups: controls, Systemic Inflammatory Response Syndrome (SIRS), infection, and sepsis, according to Sepsis-2 criteria. Results Patients with sepsis displayed higher median Sepsis Index value than patients without sepsis. At the receiver operating characterictis (ROC) curve analysis for the pr…

medicine.medical_specialtyClinical BiochemistryPopulationDiagnostic accuracyGastroenterologyMonocytesSepsisSepsisInternal medicineHumansMedicineeducationeducation.field_of_studybusiness.industryBiochemistry (medical)Curve analysisArea under the curvemonocyte distribution width (MDW)Emergency DepartmentGeneral MedicineEmergency departmentPrognosismedicine.diseaseSystemic inflammatory response syndromeROC CurveArea Under CurvebiomarkerBiomarker (medicine)mean monocyte volume (MMV)Emergency Service HospitalbusinessBiomarkersClinical Chemistry and Laboratory Medicine (CCLM)
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